Precursor miRNA: mmu-mir-291a

Precursor miRNA

Precursor Name mmu-mir-291a
Genomic Location chr7:3218919-3219000 (+); nearby genomic features
Clustered miRNAs mmu-mir-290a,mmu-mir-290b,mmu-mir-291a,mmu-mir-292a,mmu-mir-292b,mmu-mir-291b,mmu-mir-293,mmu-mir-294,mmu-mir-295 (within 10kb in genome)
NCBI GENE ID 100049715
miRBase ID MI0000389
Precursor Sequence 
         c   -  u            c  c    gagc
ccuauguag ggc ca caaaguggaggc cu ucuu    c
||||||||| ||| || |||||||||||| || ||||    
ggguacguc ccg gu guuucaccuucg ga agag    u
         a   u  -            u  a    uaag

Mature miRNA

Mature Name mmu-miR-291a-5p
Previous Name mmu-miR-291-5p
Mature Sequence 5' - caucaaaguggaggcccucucu - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0000367
Similar miRNAs mmu-miR-291b-5p (sharing the same seed sequence with mmu-miR-291a-5p).

Mature miRNA

Mature Name mmu-miR-291a-3p
Previous Name mmu-miR-291-3p
Mature Sequence 5' - aaagugcuuccacuuugugugc - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0000368
Similar miRNAs mmu-miR-294-3p, mmu-miR-295-3p, mmu-miR-302a-3p, mmu-miR-302b-3p, mmu-miR-302d-3p (sharing the same seed sequence with mmu-miR-291a-3p).

References

  • Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Shu P, Wu C, Ruan X, Liu W, Hou L, Fu H, Wang M, Liu C, Zeng Y, Chen P, Yin B, Yuan J, Qiang B, Peng X, Zhong W. Dev Cell. 2019 Jun 3;49(5):764-785.e4.

  • Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury. Borden A, Kurian J, Nickoloff E, Yang Y, Troupes CD, Ibetti J, Lucchese AM, Gao E, Mohsin S, Koch WJ, Houser SR, Kishore R, Khan M. Circ Res. 2019 Jun 21;125(1):14-25.

  • Embryonic Stem Cell-Derived mmu-miR-291a-3p Inhibits Cellular Senescence in Human Dermal Fibroblasts Through the TGF-β Receptor 2 Pathway. Bae YU, Son Y, Kim CH, Kim KS, Hyun SH, Woo HG, Jee BA, Choi JH, Sung HK, Choi HC, Park SY, Bae JH, Doh KO, Kim JR. J Gerontol A Biol Sci Med Sci. 2019 Aug 16;74(9):1359-1367.

  • The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Paikari A, D Belair C, Saw D, Blelloch R. Development. 2017 Oct 15;144(20):3731-3743.

  • Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Li Y, Taketo T, Lau YF. Methods Mol Biol. 2012;825:3-16.

  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. PLoS Biol. 2011 Jan 18;9(1):e1000582.

  • [DNA polymerase delta-interacting protein 38 is a target gene of microRNA-291a-5p]. Lin D, Lin L. Sheng Wu Gong Cheng Xue Bao. 2010 Aug;26(8):1095-101.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA. Dev Cell. 2010 Aug 17;19(2):207-19.

  • miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T. FASEB J. 2010 Sep;24(9):3255-63.

  • Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Genes Dev. 2010 May 15;24(10):992-1009.

  • MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A. Mol Hum Reprod. 2010 Jul;16(7):463-71.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • Maternal microRNAs are essential for mouse zygotic development. Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA. Genes Dev. 2007 Mar 15;21(6):644-8.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.

  • Embryonic stem cell-specific MicroRNAs. Houbaviy HB, Murray MF, Sharp PA. Dev Cell. 2003 Aug;5(2):351-8.