Mature miRNA: mmu-miR-302d-3p

Mature miRNA

miRNA Name mmu-miR-302d-3p
Previous Name mmu-miR-302d
miRNA Sequence 5' - uaagugcuuccauguuugagugu - 3' (length = 23)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0003377
Similar miRNAs mmu-miR-291a-3p, mmu-miR-294-3p, mmu-miR-295-3p, mmu-miR-302a-3p, mmu-miR-302b-3p (sharing the same seed sequence with mmu-miR-302d-3p).

Precursor miRNA

Precursor Name mmu-mir-302d
Genomic Location chr3:127545624-127545689 (+); nearby genomic features
Clustered miRNAs mmu-mir-302b,mmu-mir-302c,mmu-mir-302a,mmu-mir-302d,mmu-mir-367 (within 10kb in genome)
NCBI GENE ID 723928
miRBase ID MI0003718
Precursor Sequence 
  uu     u                cug gca
cc  uacuu aacauggaggcacuug   u   u
||  ||||| ||||||||||||||||   |   
gg  gugag uuguaccuucgugaau   a   u
  -u     u                -aa aau

References

  • Post-transcriptional regulation in cranial neural crest cells expands developmental potential. Keuls RA, Oh YS, Patel I, Parchem RJ. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2212578120.

  • Mesenchymal Stem Cell-Derived Extracellular Vesicle-Shuttled microRNA-302d-3p Represses Inflammation and Cardiac Remodeling Following Acute Myocardial Infarction. Liu Y, Guan R, Yan J, Zhu Y, Sun S, Qu Y. J Cardiovasc Transl Res. 2022 Aug;15(4):754-771.

  • LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. Circulation. 2021 May 18;143(20):2007-2022.

  • MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF. Dev Biol. 2015 Dec 1;408(1):140-50.

  • Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression. Forno I, Ferrero S, Russo MV, Gazzano G, Giangiobbe S, Montanari E, Del Nero A, Rocco B, Albo G, Languino LR, Altieri DC, Vaira V, Bosari S. PLoS One. 2015 Jun 24;10(6):e0130060.

  • A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, Snitow M, Morley M, Li D, Petrenko N, Zhou S, Lu M, Gao E, Koch WJ, Stewart KM, Morrisey EE. Sci Transl Med. 2015 Mar 18;7(279):279ra38.

  • CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes. Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, Crean JK. J Cell Sci. 2012 Dec 1;125(Pt 23):5621-9.

  • Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI. Nat Commun. 2012 Jun 26;3:923.

  • Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry. Schneider M, Andersen DC, Silahtaroglu A, Lyngbæk S, Kauppinen S, Hansen JL, Sheikh SP. J Mol Histol. 2011 Aug;42(4):289-99.

  • Regulation of lung endoderm progenitor cell behavior by miR302/367. Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE. Development. 2011 Apr;138(7):1235-45.

  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. PLoS Biol. 2011 Jan 18;9(1):e1000582.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T. FASEB J. 2010 Sep;24(9):3255-63.

  • Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Genes Dev. 2010 May 15;24(10):992-1009.

  • Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y, Archer TK. Mol Cell Biol. 2008 Oct;28(20):6426-38.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • The expression profile of microRNAs in mouse embryos. Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M, Kato I. Nucleic Acids Res. 2006 Mar 31;34(6):1765-71.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.