Mature miRNA: mmu-miR-467a-5p

Mature miRNA

miRNA Name mmu-miR-467a-5p
Previous Name mmu-miR-467*;mmu-miR-467a
miRNA Sequence 5' - uaagugccugcauguauaugcg - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0003409
Similar miRNAs mmu-miR-290a-3p, mmu-miR-292a-3p (sharing the same seed sequence with mmu-miR-467a-5p).

Precursor miRNA

Precursor Name mmu-mir-467a-1
Genomic Location chr2:10476346-10476418 (+); nearby genomic features
Clustered miRNAs mmu-mir-466m,mmu-mir-466f-1,mmu-mir-669f,mmu-mir-669e,mmu-mir-669b,mmu-mir-669d,mmu-mir-466f-2,mmu-mir-669l,mmu-mir-669d-2,mmu-mir-466f-3,mmu-mir-297a-2,mmu-mir-466o,mmu-mir-467c,mmu-mir-466b-1,mmu-mir-669a-3,mmu-mir-669k,mmu-mir-467a-1,mmu-mir-466b-8,mmu-mir-669a-1,mmu-mir-669g,mmu-mir-669j,mmu-mir-467a-2,mmu-mir-466e,mmu-mir-669a-4,mmu-mir-467b,mmu-mir-466c-1,mmu-mir-669a-5,mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4 (within 10kb in genome)
NCBI GENE ID 735286
miRBase ID MI0002402
Precursor Sequence 
c      c   a   cc  c             ua
 ugugug gua gug  ug auguauaugcgug  u
 |||||| ||| |||  || |||||||||||||   a
 acacac cau cac  ac uacauauacguau  u
u      a   c   ac  a             uu
Precursor Name mmu-mir-467a-10
Genomic Location chr2:10503273-10503355 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8,mmu-mir-466b-7,mmu-mir-669p-2,mmu-mir-467a-9,mmu-mir-466b-2,mmu-mir-669a-10,mmu-mir-669a-11,mmu-mir-467a-10,mmu-mir-466b-3,mmu-mir-669a-12,mmu-mir-467e,mmu-mir-466p,mmu-mir-467d,mmu-mir-466a,mmu-mir-297c,mmu-mir-669c,mmu-mir-669a-2,mmu-mir-297b,mmu-mir-466d,mmu-mir-669m-1 (within 10kb in genome)
NCBI GENE ID 100526539
miRBase ID MI0014076
Precursor Sequence 
u    cc     c   a   cc  c             ua
 gugc  gugug gua gug  ug auguauaugcgug  u
 ||||  ||||| ||| |||  || |||||||||||||   a
 cacg  cacac cau cac  ac uacauauacguau  u
a    ua     a   c   ac  a             uu
Precursor Name mmu-mir-467a-2
Genomic Location chr2:10478798-10478880 (+); nearby genomic features
Clustered miRNAs mmu-mir-669l,mmu-mir-669d-2,mmu-mir-466f-3,mmu-mir-297a-2,mmu-mir-466o,mmu-mir-467c,mmu-mir-466b-1,mmu-mir-669a-3,mmu-mir-669k,mmu-mir-467a-1,mmu-mir-466b-8,mmu-mir-669a-1,mmu-mir-669g,mmu-mir-669j,mmu-mir-467a-2,mmu-mir-466e,mmu-mir-669a-4,mmu-mir-467b,mmu-mir-466c-1,mmu-mir-669a-5,mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5 (within 10kb in genome)
NCBI GENE ID 100124624
miRBase ID MI0014053
Precursor Sequence 
u    c      c   a   cc  c             ua
 gugc ugugug gua gug  ug auguauaugcgug  u
 |||| |||||| ||| |||  || |||||||||||||   a
 cacg acacac cau cac  ac uacauauacguau  u
a    u      a   c   ac  a             uu
Precursor Name mmu-mir-467a-3
Genomic Location chr2:10483678-10483760 (+); nearby genomic features
Clustered miRNAs mmu-mir-467c,mmu-mir-466b-1,mmu-mir-669a-3,mmu-mir-669k,mmu-mir-467a-1,mmu-mir-466b-8,mmu-mir-669a-1,mmu-mir-669g,mmu-mir-669j,mmu-mir-467a-2,mmu-mir-466e,mmu-mir-669a-4,mmu-mir-467b,mmu-mir-466c-1,mmu-mir-669a-5,mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7 (within 10kb in genome)
NCBI GENE ID 100124642
miRBase ID MI0014056
Precursor Sequence 
u    cc     c   a   cc  c             ua
 gugc  gugug gua gug  ug auguauaugcgug  u
 ||||  ||||| ||| |||  || |||||||||||||   a
 cacg  cacac cau cac  ac uacauauacguau  u
a    ua     a   c   ac  a             uu
Precursor Name mmu-mir-467a-4
Genomic Location chr2:10486135-10486217 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-1,mmu-mir-466b-8,mmu-mir-669a-1,mmu-mir-669g,mmu-mir-669j,mmu-mir-467a-2,mmu-mir-466e,mmu-mir-669a-4,mmu-mir-467b,mmu-mir-466c-1,mmu-mir-669a-5,mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8 (within 10kb in genome)
NCBI GENE ID 100124625
miRBase ID MI0014059
Precursor Sequence 
u    c      c   a   cc  c             ua
 gugc ugugug gua gug  ug auguauaugcgug  u
 |||| |||||| ||| |||  || |||||||||||||   a
 cacg acacac cau cac  ac uacauauacguau  u
a    u      a   c   ac  a             uu
Precursor Name mmu-mir-467a-5
Genomic Location chr2:10488599-10488681 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-2,mmu-mir-466e,mmu-mir-669a-4,mmu-mir-467b,mmu-mir-466c-1,mmu-mir-669a-5,mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8,mmu-mir-466b-7,mmu-mir-669p-2,mmu-mir-467a-9 (within 10kb in genome)
NCBI GENE ID 100124626
miRBase ID MI0014062
Precursor Sequence 
u    c      c   a   cc  c             ua
 gugc ugugug gua gug  ug auguauaugcgug  u
 |||| |||||| ||| |||  || |||||||||||||   a
 cacg acacac cau cac  ac uacauauacguau  u
a    u      a   c   ac  a             uu
Precursor Name mmu-mir-467a-6
Genomic Location chr2:10491048-10491130 (+); nearby genomic features
Clustered miRNAs mmu-mir-467b,mmu-mir-466c-1,mmu-mir-669a-5,mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8,mmu-mir-466b-7,mmu-mir-669p-2,mmu-mir-467a-9,mmu-mir-466b-2,mmu-mir-669a-10 (within 10kb in genome)
NCBI GENE ID 100124627
miRBase ID MI0014065
Precursor Sequence 
u    cc     c   a   cc  c             ua
 gugc  gugug gua gug  ug auguauaugcgug  u
 ||||  ||||| ||| |||  || |||||||||||||   a
 cacg  cacac cau cac  ac uacauauacguau  u
a    ua     a   c   ac  a             uu
Precursor Name mmu-mir-467a-7
Genomic Location chr2:10493510-10493592 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-3,mmu-mir-466c-2,mmu-mir-669a-6,mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8,mmu-mir-466b-7,mmu-mir-669p-2,mmu-mir-467a-9,mmu-mir-466b-2,mmu-mir-669a-10,mmu-mir-669a-11,mmu-mir-467a-10 (within 10kb in genome)
NCBI GENE ID 100526553
miRBase ID MI0014069
Precursor Sequence 
u    c      c   a   cc  c             ua
 gugc ugugug gua gug  ug auguauaugcgug  u
 |||| |||||| ||| |||  || |||||||||||||   a
 cacg acacac cau cac  ac uacauauacguau  u
a    u      a   c   ac  a             uu
Precursor Name mmu-mir-467a-8
Genomic Location chr2:10495980-10496062 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-4,mmu-mir-466b-4,mmu-mir-669a-7,mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8,mmu-mir-466b-7,mmu-mir-669p-2,mmu-mir-467a-9,mmu-mir-466b-2,mmu-mir-669a-10,mmu-mir-669a-11,mmu-mir-467a-10,mmu-mir-466b-3,mmu-mir-669a-12,mmu-mir-467e (within 10kb in genome)
NCBI GENE ID 100124643
miRBase ID MI0014072
Precursor Sequence 
u    c      c   a   cc  c             ua
 gugc ugugug gua gug  ug auguauaugcgug  u
 |||| |||||| ||| |||  || |||||||||||||   a
 cacg acacac cau cac  ac uacauauacguau  u
a    u      a   c   ac  a             uu
Precursor Name mmu-mir-467a-9
Genomic Location chr2:10498393-10498475 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-5,mmu-mir-466b-5,mmu-mir-669p-1,mmu-mir-467a-6,mmu-mir-466c-3,mmu-mir-669a-8,mmu-mir-467a-7,mmu-mir-466b-6,mmu-mir-669a-9,mmu-mir-467a-8,mmu-mir-466b-7,mmu-mir-669p-2,mmu-mir-467a-9,mmu-mir-466b-2,mmu-mir-669a-10,mmu-mir-669a-11,mmu-mir-467a-10,mmu-mir-466b-3,mmu-mir-669a-12,mmu-mir-467e,mmu-mir-466p,mmu-mir-467d,mmu-mir-466a (within 10kb in genome)
NCBI GENE ID 100526554
miRBase ID MI0014074
Precursor Sequence 
u    c      c   a   cc  c             ua
 gugc ugugug gua gug  ug auguauaugcgug  u
 |||| |||||| ||| |||  || |||||||||||||   a
 cacg acacac cau cac  ac uacauauacguau  u
a    u      a   c   ac  a             uu

References

  • MiR-467a-5p aggravates myocardial infarction by modulating ZEB1 expression in mice. Huang W, Cao Y, Chen C, Wu X, Sheng Z, Li A. J Mol Histol. 2021 Aug;52(4):767-780.

  • miR-467 regulates inflammation and blood insulin and glucose. Gajeton J, Krukovets I, Yendamuri R, Verbovetskiy D, Vasanji A, Sul L, Stenina-Adognravi O. J Cell Mol Med. 2021 Mar;25(5):2549-2562.

  • miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Gu QH, Yu D, Hu Z, Liu X, Yang Y, Luo Y, Zhu J, Li Z. Nat Commun. 2015 Apr 10;6:6789.

  • MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. Gao F, Chen S, Sun M, Mitchel RE, Li B, Chu Z, Cai J, Liu C. Int J Biol Sci. 2015 Jan 1;11(1):109-21.

  • Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss. Zhang Q, Liu H, McGee J, Walsh EJ, Soukup GA, He DZ. PLoS One. 2013 Apr 30;8(4):e62786.

  • Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2. Polikepahad S, Corry DB. Nucleic Acids Res. 2013 Jan;41(2):1164-77.

  • Genome-wide impact of a recently expanded microRNA cluster in mouse. Zheng GX, Ravi A, Gould GM, Burge CB, Sharp PA. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15804-9.

  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. PLoS Biol. 2011 Jan 18;9(1):e1000582.

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  • miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T. FASEB J. 2010 Sep;24(9):3255-63.

  • Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Genes Dev. 2010 May 15;24(10):992-1009.

  • MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A. Mol Hum Reprod. 2010 Jul;16(7):463-71.

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  • The expression profile of microRNAs in mouse embryos. Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M, Kato I. Nucleic Acids Res. 2006 Mar 31;34(6):1765-71.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.

  • MicroRNA Mirn122a reduces expression of the posttranscriptionally regulated germ cell transition protein 2 (Tnp2) messenger RNA (mRNA) by mRNA cleavage. Yu Z, Raabe T, Hecht NB. Biol Reprod. 2005 Sep;73(3):427-33.