Mature miRNA: hsa-miR-521

Mature miRNA

miRNA Name hsa-miR-521
miRNA Sequence 5' - aacgcacuucccuuuagagugu - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
Targeted Pathways miRDB
Expression Profile Display table
miRBase ID MIMAT0002854

Precursor miRNA

Precursor Name hsa-mir-521-1
Genomic Location chr19:53748636-53748722 (+); nearby genomic features
Clustered miRNAs hsa-mir-518a-2,hsa-mir-517c,hsa-mir-520h,hsa-mir-521-1,hsa-mir-522,hsa-mir-519a-1,hsa-mir-527,hsa-mir-516a-1,hsa-mir-1283-2 (within 10kb in genome)
NCBI GENE ID 574494
miRBase ID MI0003176
Precursor Sequence 
     g  u     c   c         aa u    guug  u
ucuca gc gugac cuc aaagggaag  c uucu    uc a
||||| || ||||| ||| |||||||||  | ||||    ||  a
agagu ug cauug gag uuucccuuc  g aaga    ag a
     g  c     u   a         ac c    --aa  a
Precursor Name hsa-mir-521-2
Genomic Location chr19:53716594-53716680 (+); nearby genomic features
Clustered miRNAs hsa-mir-520c,hsa-mir-518c,hsa-mir-524,hsa-mir-517a,hsa-mir-519d,hsa-mir-521-2,hsa-mir-520d,hsa-mir-517b,hsa-mir-520g,hsa-mir-516b-2 (within 10kb in genome)
NCBI GENE ID 574481
miRBase ID MI0003163
Precursor Sequence 
     g  u     u   c         ---aa    c    gu
ucucg gc gugac cuc aaagggaag     uuuu ucuu  c
||||| || ||||| ||| |||||||||     |||| ||||  
agagu ug cauug gag uuucccuuc     agaa agaa  u
     g  c     u   a         acgca    a    aa

References

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.

  • Identification of hundreds of conserved and nonconserved human microRNAs. Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z. Nat Genet. 2005 Jul;37(7):766-70.