Precursor miRNA: mmu-mir-494

Precursor miRNA

Precursor Name mmu-mir-494
Genomic Location chr12:109715318-109715402 (+); nearby genomic features
Clustered miRNAs mmu-mir-379,mmu-mir-411,mmu-mir-299a,mmu-mir-299b,mmu-mir-380,mmu-mir-1197,mmu-mir-323,mmu-mir-758,mmu-mir-329,mmu-mir-494,mmu-mir-679,mmu-mir-1193,mmu-mir-666,mmu-mir-543,mmu-mir-495,mmu-mir-667,mmu-mir-376c,mmu-mir-654,mmu-mir-376b,mmu-mir-376a,mmu-mir-300 (within 10kb in genome)
NCBI GENE ID 723878
miRBase ID MI0003532
Precursor Sequence 
u       u            gu      -   c   -  uuu
 ugauacu gaaggagagguu  ccgugu ugu uuc uc   a
 ||||||| ||||||||||||  |||||| ||| ||| ||    u
 acuauga uuuuuucuccaa  ggcaca aca aag ag   u
a       -            ag      u   -   u  uau

Mature miRNA

Mature Name mmu-miR-494-3p
Previous Name mmu-miR-494
Mature Sequence 5' - ugaaacauacacgggaaaccuc - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0003182

References

  • MicroRNA-495 Modulates Neuronal Layer Fate Determination by Targeting Pang Y, Ruan X, Liu W, Hou L, Yin B, Shu P, Peng X. Int J Biol Sci. 2024 Nov 11;20(15):6207-6221.

  • [LncRNA SNHG8 inhibits miR-494-3p expression to alleviate cerebral ischemia-reperfusion injury in mice]. Cao T, Liu Q, Pan M, Zhang X. Nan Fang Yi Ke Da Xue Xue Bao. 2023 Dec 20;43(12):2015-2022.

  • MiR-494-3p aggravates pirarubicin-induced cardiomyocyte injury by regulating MDM4/p53 signaling pathway. Huang P, Zhang Y, Wang F, Qin M, Ma J, Ji J, Wei D, Ren L. Environ Toxicol. 2023 Oct;38(10):2499-2508.

  • Linoleic Acid Upregulates Microrna-494 to Induce Quiescence in Colorectal Cancer. Ogata R, Mori S, Kishi S, Sasaki R, Iwata N, Ohmori H, Sasaki T, Nishiguchi Y, Nakashima C, Goto K, Kawahara I, Fujiwara-Tani R, Kuniyasu H. Int J Mol Sci. 2021 Dec 25;23(1):225.

  • Regulation mechanism of miR-494-3p on endometrial receptivity in mice via PI3K/AKT/mTOR pathway. Yuan L, Feng F, Mao Z, Huang JZ, Liu Y, Li YL, Jiang RX. Gen Physiol Biophys. 2021 Sep;40(5):351-363.

  • Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis. Ding A, Li CH, Yu CY, Zhou HT, Zhang ZH. Lab Invest. 2021 Nov;101(11):1458-1466.

  • MiR-494-mediated Effects on the NF-κB Signaling Pathway Regulate Lipopolysaccharide-Induced Acute Kidney Injury in Mice. Lu P, Zhang L, Liu T, Fan JJ, Luo X, Zhu YT. Immunol Invest. 2022 Jul;51(5):1372-1384.

  • MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells. Iwasaki H, Ichihara Y, Morino K, Lemecha M, Sugawara L, Sawano T, Miake J, Sakurai H, Nishi E, Maegawa H, Imamura T. Sci Rep. 2021 Jan 13;11(1):1161.

  • MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3. Li H, Zhang L, Cai N, Zhang B, Sun S. Ann Hepatol. 2021 Jul-Aug;23:100305.

  • Dendritic cell‑derived exosomal miR‑494‑3p promotes angiogenesis following myocardial infarction. Liu H, Zhang Y, Yuan J, Gao W, Zhong X, Yao K, Lin L, Ge J. Int J Mol Med. 2021 Jan;47(1):315-325.

  • Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L. Tian RH, Guo KM, Han GH, Bai Y. Exp Mol Pathol. 2020 Aug;115:104452.

  • Inhibition of histone deacetylase 3 by MiR-494 alleviates neuronal loss and improves neurological recovery in experimental stroke. Zhao H, Li G, Zhang S, Li F, Wang R, Tao Z, Ma Q, Han Z, Yan F, Fan J, Li L, Ji X, Luo Y. J Cereb Blood Flow Metab. 2019 Dec;39(12):2392-2405.

  • Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke. Zhao H, Li G, Wang R, Tao Z, Ma Q, Zhang S, Han Z, Yan F, Li F, Liu P, Ma S, Ji X, Luo Y. Br J Pharmacol. 2020 Jan;177(1):128-144.

  • Mir-494 inhibits osteoblast differentiation by regulating BMP signaling in simulated microgravity. Qin W, Liu L, Wang Y, Wang Z, Yang A, Wang T. Endocrine. 2019 Aug;65(2):426-439.

  • MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6. Wang HF, Li Y, Wang YQ, Li HJ, Dou L. Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2971-2977.

  • MicroRNA‑494 inhibits apoptosis of murine vascular smooth muscle cells in vitro. Cui R, Ye S, Zhong J, Liu L, Li S, Lin X, Yuan L, Yi L. Mol Med Rep. 2019 May;19(5):4457-4467.

  • miR‑494‑3p regulates lipopolysaccharide‑induced inflammatory responses in RAW264.7 cells by targeting PTEN. Zhang S, He K, Zhou W, Cao J, Jin Z. Mol Med Rep. 2019 May;19(5):4288-4296.

  • Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy. Costantino S, Akhmedov A, Melina G, Mohammed SA, Othman A, Ambrosini S, Wijnen WJ, Sada L, Ciavarella GM, Liberale L, Tanner FC, Matter CM, Hornemann T, Volpe M, Mechta-Grigoriou F, Camici GG, Sinatra R, Lüscher TF, Paneni F. Eur Heart J. 2019 Mar 21;40(12):997-1008.

  • MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes. Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, Sato D, Sekine O, Ugi S, Maegawa H. Sci Rep. 2018 Oct 10;8(1):15096.

  • miR-494-3p is a novel tumor driver of lung carcinogenesis. Faversani A, Amatori S, Augello C, Colombo F, Porretti L, Fanelli M, Ferrero S, Palleschi A, Pelicci PG, Belloni E, Ercoli G, Degrassi A, Baccarin M, Altieri DC, Vaira V, Bosari S. Oncotarget. 2017 Jan 31;8(5):7231-7247.

    • There are 44 references associated with mmu-mir-494. Click here to see the complete list in PubMed.