Mature miRNA: mmu-miR-466d-3p

Mature miRNA

miRNA Name mmu-miR-466d-3p
miRNA Sequence 5' - uauacauacacgcacacauag - 3' (length = 21)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0004931
Similar miRNAs mmu-miR-297a-3p, mmu-miR-297b-3p, mmu-miR-297c-3p, mmu-miR-466a-3p, mmu-miR-466e-3p, mmu-miR-467g, mmu-miR-669d-3p (sharing the same seed sequence with mmu-miR-466d-3p).

Precursor miRNA

Precursor Name mmu-mir-466d
Genomic Location chr2:10511967-10512062 (+); nearby genomic features
Clustered miRNAs mmu-mir-467a-10,mmu-mir-466b-3,mmu-mir-669a-12,mmu-mir-467e,mmu-mir-466p,mmu-mir-467d,mmu-mir-466a,mmu-mir-297c,mmu-mir-669c,mmu-mir-669a-2,mmu-mir-297b,mmu-mir-466d,mmu-mir-669m-1,mmu-mir-669m-2,mmu-mir-466n,mmu-mir-669o,mmu-mir-466g,mmu-mir-466h,mmu-mir-297a-3,mmu-mir-466l,mmu-mir-297a-4,mmu-mir-669i,mmu-mir-669h (within 10kb in genome)
NCBI GENE ID 100124465
miRBase ID MI0005546
Precursor Sequence 
--ca       u            - -    --a a            aa
    ugugugu ugugugugcgua c augu   c uguguguauaug  u
    ||||||| |||||||||||| | ||||   | ||||||||||||  
    acacaca acacgcacgcau g uaca   g acauacauauac  a
ggac       c            a a    cac c            au

References

  • Degradation of MicroRNA miR-466d-3p by Japanese Encephalitis Virus NS3 Facilitates Viral Replication and Interleukin-1β Expression. Jiang H, Bai L, Ji L, Bai Z, Su J, Qin T, Wang G, Balasubramaniam V, Wang X, Cui M, Ye J, Cao S, Li G, Yang Y. J Virol. 2020 Jul 16;94(15):e00294-20.

  • Differential expression of microRNAs in 2-cell and 4-cell mouse embryos. Wang P, Cui J, Zhao C, Zhou L, Guo X, Shen R, Zhang J, Ling X. Zygote. 2014 Nov;22(4):455-61.

  • Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2. Polikepahad S, Corry DB. Nucleic Acids Res. 2013 Jan;41(2):1164-77.

  • Upregulation of Cyclin B1 by miRNA and its implications in cancer. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Nucleic Acids Res. 2012 Feb;40(4):1695-707.

  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. PLoS Biol. 2011 Jan 18;9(1):e1000582.

  • Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Genes Dev. 2010 May 15;24(10):992-1009.

  • MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A. Mol Hum Reprod. 2010 Jul;16(7):463-71.

  • RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Calabrese JM, Seila AC, Yeo GW, Sharp PA. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18097-102.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.