Mature miRNA: mmu-miR-297a-3p

Mature miRNA

miRNA Name mmu-miR-297a-3p
Previous Name mmu-miR-297a*
miRNA Sequence 5' - uauacauacacacauacccaua - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0004864
Similar miRNAs mmu-miR-297b-3p, mmu-miR-297c-3p, mmu-miR-466a-3p, mmu-miR-466d-3p, mmu-miR-466e-3p, mmu-miR-467g, mmu-miR-669d-3p (sharing the same seed sequence with mmu-miR-297a-3p).

Precursor miRNA

Precursor Name mmu-mir-297a-3
Genomic Location chr2:10515820-10515921 (+); nearby genomic features
Clustered miRNAs mmu-mir-466p,mmu-mir-467d,mmu-mir-466a,mmu-mir-297c,mmu-mir-669c,mmu-mir-669a-2,mmu-mir-297b,mmu-mir-466d,mmu-mir-669m-1,mmu-mir-669m-2,mmu-mir-466n,mmu-mir-669o,mmu-mir-466g,mmu-mir-466h,mmu-mir-297a-3,mmu-mir-466l,mmu-mir-297a-4,mmu-mir-669i,mmu-mir-669h (within 10kb in genome)
NCBI GENE ID 100124482
miRBase ID MI0005488
Precursor Sequence 
--------        auaugua           ------------gca            aa
        cugugugu       ugugugcaugu               uguguguauaug  u
        ||||||||       |||||||||||               ||||||||||||  
        gacacaca       acacacguaca               acauacauauac  a
aguuaaaa        ------a           aacauacccauacac            au
Precursor Name mmu-mir-297a-4
Genomic Location chr2:10517067-10517164 (+); nearby genomic features
Clustered miRNAs mmu-mir-467d,mmu-mir-466a,mmu-mir-297c,mmu-mir-669c,mmu-mir-669a-2,mmu-mir-297b,mmu-mir-466d,mmu-mir-669m-1,mmu-mir-669m-2,mmu-mir-466n,mmu-mir-669o,mmu-mir-466g,mmu-mir-466h,mmu-mir-297a-3,mmu-mir-466l,mmu-mir-297a-4,mmu-mir-669i,mmu-mir-669h (within 10kb in genome)
NCBI GENE ID 100124435
miRBase ID MI0005489
Precursor Sequence 
--c         a   a       ----------     ca            ag
   uguguguau ugu ugugugc          augug  uguguguauaug  u
   ||||||||| ||| |||||||          |||||  ||||||||||||  
   acgcacaua aca acguacg          uacac  acauacauauac  a
aaa         a   c       aacauaccca     --            au

References

  • Genome-wide impact of a recently expanded microRNA cluster in mouse. Zheng GX, Ravi A, Gould GM, Burge CB, Sharp PA. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15804-9.

  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. PLoS Biol. 2011 Jan 18;9(1):e1000582.

  • Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Genes Dev. 2010 May 15;24(10):992-1009.

  • MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A. Mol Hum Reprod. 2010 Jul;16(7):463-71.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.