Mature miRNA: hsa-miR-548a-5p

Mature miRNA

miRNA Name hsa-miR-548a-5p
miRNA Sequence 5' - aaaaguaauugcgaguuuuacc - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0004803
Similar miRNAs hsa-miR-548ab, hsa-miR-548ad-5p, hsa-miR-548ae-5p, hsa-miR-548ak, hsa-miR-548am-5p, hsa-miR-548ap-5p, hsa-miR-548aq-5p, hsa-miR-548ar-5p, hsa-miR-548as-5p, hsa-miR-548au-5p, hsa-miR-548ay-5p, hsa-miR-548b-5p, hsa-miR-548bb-5p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-548h-5p, hsa-miR-548i, hsa-miR-548j-5p, hsa-miR-548o-5p, hsa-miR-548w, hsa-miR-548y, hsa-miR-559 (sharing the same seed sequence with hsa-miR-548a-5p).

Precursor miRNA

Precursor Name hsa-mir-548a-3
Genomic Location chr8:104484369-104484465 (-); nearby genomic features
NCBI GENE ID 693127
miRBase ID MI0003612
Precursor Sequence 
ccuagaaugu     g  c                 g      a     ac
          uauua gu ggugcaaaaguaauugc aguuuu ccauu  u
          ||||| || ||||||||||||||||| |||||| |||||  
          auaau ca ccacguuuucauuaacg ucaaaa gguaa  u
-------uuc     g  a                 g      c     cu

References

  • Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study. Motaei J, Kerachian MA, Mousavi SA, Alimoghadam K, Ghavamzadeh A, Manoochehrabadi S, Ahmadvand M, Yaghmaie M. Ann Hematol. 2021 Oct;100(10):2621-2631.

  • miR-548a-3p Weakens the Tumorigenesis of Colon Cancer Through Targeting TPX2. Wang M, Yang M, Deng B. Cancer Biother Radiopharm. 2022 Dec;37(10):917-926.

  • Elevated expression of circular RNA circ_0008450 predicts dismal prognosis in hepatocellular carcinoma and regulates cell proliferation, apoptosis, and invasion via sponging miR-548p. Zhang J, Chang Y, Xu L, Qin L. J Cell Biochem. 2019 Jun;120(6):9487-9494.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • The colorectal microRNAome. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.