Mature miRNA: hsa-miR-1827

Mature miRNA

miRNA Name hsa-miR-1827
miRNA Sequence 5' - ugaggcaguagauugaau - 3' (length = 18)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0006767

Precursor miRNA

Precursor Name hsa-mir-1827
Genomic Location chr12:100189884-100189949 (+); nearby genomic features
NCBI GENE ID 100302217
miRBase ID MI0008195
Precursor Sequence 
--    - a  aca    u      aaag  au   a
  ucag c gc   gccu cagccu    ca  gag a
  |||| | ||   |||| ||||||    ||  ||| 
  aguu g ug   cgga gucgga    gu  cuc g
ua    a a  --a    -      --aa  --   c

References

  • Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease. Li M, Zeng A, Tang X, Xu H, Xiong W, Guo Y. Sci Rep. 2023 Nov 13;13(1):19807.

  • Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis. Chen J, Li Z, Yue C, Ma J, Cao L, Lin J, Zhu D, An R, Lai J, Guo Y, Gu B. Apoptosis. 2023 Apr;28(3-4):549-565.

  • LINC00092 Suppresses the Malignant Progression of Breast Invasive Ductal Carcinoma Through Modulating SFRP1 Expression by Sponging miR-1827. Zhao CM, Li LL, Xu JW, Li ZW, Shi P, Jiang R. Cell Transplant. 2022 Jan-Dec;31:9636897221086967.

  • MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia. Davarinejad O, Najafi S, Zhaleh H, Golmohammadi F, Radmehr F, Alikhani M, Moghadam RH, Rahmati Y. J Mol Neurosci. 2022 Feb;72(2):226-238.

  • TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827. Shen A, Tong X, Li H, Chu L, Jin X, Ma H, Ouyang Y. Clin Exp Pharmacol Physiol. 2021 Jun;48(6):890-901.

  • The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1. Guo X, Wang Z, Sun Q, Sun C, Hua H, Huang Q. Acta Biochim Biophys Sin (Shanghai). 2020 Oct 19;52(10):1148-1155.

  • MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F. Fan G, Xu P, Tu P. J Cell Biochem. 2020 Feb;121(2):1675-1689.

  • miR-1827 inhibits osteogenic differentiation by targeting IGF1 in MSMSCs. Zhu S, Peng W, Li X, Weng J, Zhang X, Guo J, Huang D, Rong Q, Chen S. Sci Rep. 2017 Apr 7;7:46136.

  • microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. Zhang C, Liu J, Tan C, Yue X, Zhao Y, Peng J, Wang X, Laddha SV, Chan CS, Zheng S, Hu W, Feng Z. Oncotarget. 2016 Feb 23;7(8):8783-96.

  • Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer. Xiong F, Wu C, Chang J, Yu D, Xu B, Yuan P, Zhai K, Xu J, Tan W, Lin D. Cancer Res. 2011 Aug 1;71(15):5175-81.

  • Discovering microRNAs from deep sequencing data using miRDeep. Friedländer MR, Chen W, Adamidi C, Maaskola J, Einspanier R, Knespel S, Rajewsky N. Nat Biotechnol. 2008 Apr;26(4):407-15.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.