Mature miRNA: hsa-miR-645

Mature miRNA

miRNA Name hsa-miR-645
miRNA Sequence 5' - ucuaggcugguacugcuga - 3' (length = 19)
Predicted Targets miRDB
Validated Targets TarBase
Targeted Pathways miRDB
miRBase ID MIMAT0003315

Precursor miRNA

Precursor Name hsa-mir-645
Genomic Location chr20:50585786-50585879 (+); nearby genomic features
NCBI GENE ID 693230
miRBase ID MI0003660
Precursor Sequence 
caguuccuaac    c    ac             u   cu       
           aggc ucag  caguaccggucug ggc  ggggguug
           |||| ||||  ||||||||||||| |||  ||||||| a
           uucg aguc  gucauggucggau ucg  uccccagg
-gagagaaaaa    u    --             c   --

References

  • MiR-645 promotes proliferation and migration of non-small cell lung cancer cells by targeting TP53I11. Zhu B, Tian T, Zhao M. Eur Rev Med Pharmacol Sci. 2020 Jun;24(11):6150-6156.

  • MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1. Wang R, Shen J, Su N, Wang Q, Zhang M, Liu C. Hum Cell. 2020 Oct;33(4):1091-1098.

  • MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation. Tao J, Liu Z, Wang Y, Wang L, Yin G, Yang W, Tu K, Liu Q. Int J Biol Macromol. 2019 Jan;121:214-222.

  • MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2. Jiao GJ, Zhang SJ, Li Y, Wu WL, Liu HC. Clin Exp Pharmacol Physiol. 2018 Dec;45(12):1317-1324.

  • MicroRNA-645 promotes cell metastasis and proliferation of renal clear cell carcinoma by targeting GK5. Chen J, Shu Y, Yu Q, Shen W. Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4557-4565.

  • Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2. Cai Y, Li WF, Sun Y, Liu K. Eur Rev Med Pharmacol Sci. 2017 Sep;21(18):4129-4136.

  • Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. Wang Y, Zhang L, Zheng X, Zhong W, Tian X, Yin B, Tian K, Zhang W. Cancer Lett. 2016 Nov 28;382(2):137-146.

  • MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2. Feng X, Wang Y, Ma Z, Yang R, Liang S, Zhang M, Song S, Li S, Liu G, Fan D, Gao S. BMC Cancer. 2014 Aug 29;14:633.

  • The colorectal microRNAome. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.