Mature miRNA: hsa-miR-597-3p

Mature miRNA

miRNA Name hsa-miR-597-3p
miRNA Sequence 5' - ugguucucuuguggcucaagcgu - 3' (length = 23)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0026619

Precursor miRNA

Precursor Name hsa-mir-597
Genomic Location chr8:9741672-9741768 (+); nearby genomic features
NCBI GENE ID 693182
miRBase ID MI0003609
Precursor Sequence 
u   --          -----g  u     uc  u         gaag   gu
 acu  uacucuacgu      ug gucac  ga gaccacugu    aca  a
 |||  ||||||||||      || |||||  || |||||||||    |||  
 ugg  augagaugua      ac cggug  cu uuggugaca    ugu  a
c   uc          augcga  u     uu  c         ----   aa

References

  • Proximal tubular MBD2 promotes autophagy to drive the progression of AKI caused by vancomycin via regulation of miR-597-5p/S1PR1 axis. Guo Y, Wu D, Li X, Wang J, Li H, Li Y, Luo D, Yi F, Zhang D. FASEB J. 2024 Apr 15;38(7):e23562.

  • Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition. Kang SH, Kim HB, Choi JS. Eur J Haematol. 2022 Dec;109(6):680-685.

  • MiR-597-5p suppresses the progression of hepatocellular carcinoma via targeting transcriptional enhancer associate domain transcription factor 1 (TEAD1). Sun X, Hou Z, Li N, Zhang S. In Vitro Cell Dev Biol Anim. 2022 Feb;58(2):96-108.

  • LncRNA GSTM3TV2 Promotes Cell Proliferation and Invasion via miR-597/FOSL2 Axis in Hepatocellular Carcinoma. Hu Y, Qiu W, Kong Z, Wu S, Liu Y, Zhu C, Qin X. Biomed Res Int. 2021 Aug 17;2021:3445970.

  • Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA‑597‑3p/FOSL2 pathway. Gao L, Jin HJ, Zhang D, Lin Q. Int J Mol Med. 2020 Nov;46(5):1653-1660.

  • miR-597-5p inhibits cell growth and promotes cell apoptosis by targeting ELK1 in pancreatic cancer. Li S, Li X, Xing X, Wang L. Hum Cell. 2020 Oct;33(4):1165-1175.

  • MicroRNA-597 inhibits NSCLC progression through negatively regulating CDK2 expression. Yu DJ, Li YH, Zhong M. Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4288-4297.

  • Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression. Chen Z, Ren R, Wan D, Wang Y, Xue X, Jiang M, Shen J, Han Y, Liu F, Shi J, Kuang Y, Li W, Zhi Q. Oncogene. 2019 Aug;38(32):6017-6034.

  • MiR-597 Targeting 14-3-3σ Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells. Xie L, Jiang T, Cheng A, Zhang T, Huang P, Li P, Wen G, Lei F, Huang Y, Tang X, Gong J, Lin Y, Kuai J, Huang W. Curr Mol Pharmacol. 2019;12(2):105-114.

  • miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2. He J, Mai J, Li Y, Chen L, Xu H, Zhu X, Pan Q. Oncol Rep. 2017 May;37(5):2672-2678.

  • Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S; Acne Genetic Study Group; Willis C, Déret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN. Nat Commun. 2014 Jun 13;5:4020.

  • Birth and expression evolution of mammalian microRNA genes. Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H. Genome Res. 2013 Jan;23(1):34-45.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • The colorectal microRNAome. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.