Mature miRNA: hsa-miR-561-5p

Mature miRNA

miRNA Name hsa-miR-561-5p
miRNA Sequence 5' - aucaaggaucuuaaacuuugcc - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0022706

Precursor miRNA

Precursor Name hsa-mir-561
Genomic Location chr2:188297492-188297588 (+); nearby genomic features
NCBI GENE ID 693146
miRBase ID MI0003567
Precursor Sequence 
cuucauccaccag            a                     agag
             uccuccaggaac ucaaggaucuuaaacuuugcc    c
             |||||||||||| |||||||||||||||||||||     u
             aggggguccuug aguuccuagaauuugaaacgg    a
--------uacca            a                     aaac

References

  • NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis. Wang CS, Zhang XB, Zhu XT, Chen RS. Neoplasma. 2022 Sep;69(5):1165-1174.

  • MicroRNA-561-5p Inhibits Cell Proliferation and Invasion by Targeting RAC1 in Pancreatic Ductal Adenocarcinoma. Xi B, Lai M, Zhang W, Wang F. Ann Clin Lab Sci. 2022 Mar;52(2):213-221.

  • Circular RNA circHIPK3 Activates Macrophage NLRP3 Inflammasome and TLR4 Pathway in Gouty Arthritis via Sponging miR-561 and miR-192. Lian C, Sun J, Guan W, Zhang L, Zhang X, Yang L, Hu W. Inflammation. 2021 Oct;44(5):2065-2077.

  • MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. Liao Z, Zheng Q, Wei T, Zhang Y, Ma J, Zhao Z, Sun H, Nan K. Oncol Res. 2020 Mar 27;28(2):147-159.

  • The miR-561-5p/CX Chen EB, Zhou ZJ, Xiao K, Zhu GQ, Yang Y, Wang B, Zhou SL, Chen Q, Yin D, Wang Z, Shi YH, Gao DM, Chen J, Zhao Y, Wu WZ, Fan J, Zhou J, Dai Z. Theranostics. 2019 Jul 9;9(16):4779-4794.

  • Hsa_circ_0002468 Regulates the Neuronal Differentiation of SH-SY5Y Cells by Modulating the MiR-561/E2F8 Axis. Yang M, Xiang G, Yu D, Yang G, He W, Yang S, Zhou G, Liu A. Med Sci Monit. 2019 Apr 5;25:2511-2519.

  • Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years. Guan X, Liu H, Ju J, Li Y, Li P, Wang LE, Brewster AM, Buchholz TA, Arun BK, Wei Q, Liu Z. Mol Carcinog. 2015 Apr;54(4):281-90.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • The colorectal microRNAome. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.