Mature miRNA: hsa-miR-557

Mature miRNA

miRNA Name hsa-miR-557
miRNA Sequence 5' - guuugcacgggugggccuugucu - 3' (length = 23)
Predicted Targets miRDB
Validated Targets TarBase
Targeted Pathways miRDB
miRBase ID MIMAT0003221
Similar miRNAs hsa-miR-507 (sharing the same seed sequence with hsa-miR-557).

Precursor miRNA

Precursor Name hsa-mir-557
Genomic Location chr1:168375524-168375621 (+); nearby genomic features
NCBI GENE ID 693142
miRBase ID MI0003563
Precursor Sequence 
agaaugggcaaaugaacaguaaa  ug     cu       u   -   ---u   g
                       uu  gaggc  ggggccc ccc ugc    gcu g
                       ||  |||||  ||||||| ||| |||    |||  a
                       aa  uucug  uuccggg ggg acg    uga g
-------------agguggagga  gu     --       u   c   uuug   a

References

  • miR-557 inhibits hepatocellular carcinoma progression through Wnt/β-catenin signaling pathway by targeting RAB10. Cheng X, Wu C, Xu H, Zou R, Li T, Ye S. Aging (Albany NY). 2024 Feb 15;16(4):3716-3733.

  • circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557. Zhu K, Yi C, Tong C. Cancer Biomark. 2024;39(1):1-13.

  • The role and mechanism of miR-557 in inhibiting the differentiation and maturation of megakaryocytes in immune thrombocytopenia. Wang Y, Guo Y, Zhang X, Zhao H, Zhang B, Wu Y, Zhang J. RNA Biol. 2021 Nov;18(11):1953-1968.

  • MiR-557 works as a tumor suppressor in human lung cancers by negatively regulating LEF1 expression. Qiu J, Hao Y, Huang S, Ma Y, Li X, Li D, Mao Y. Tumour Biol. 2017 Jun;39(6):1010428317709467.

  • The colorectal microRNAome. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.