Mature miRNA: hsa-miR-518c-5p

Mature miRNA

miRNA Name hsa-miR-518c-5p
Previous Name hsa-miR-518c*
miRNA Sequence 5' - ucucuggagggaagcacuuucug - 3' (length = 23)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0002847

Precursor miRNA

Precursor Name hsa-mir-518c
Genomic Location chr19:53708735-53708835 (+); nearby genomic features
Clustered miRNAs hsa-mir-518f,hsa-mir-520b,hsa-mir-518b,hsa-mir-526a-1,hsa-mir-520c,hsa-mir-518c,hsa-mir-524,hsa-mir-517a,hsa-mir-519d,hsa-mir-521-2 (within 10kb in genome)
NCBI GENE ID 574477
miRBase ID MI0003159
Precursor Sequence 
gcgagaaga     u        u              a   uc    g  u
         ucuca gcugugac cucuggagggaagc cuu  uguu uc g
         ||||| |||||||| |||||||||||||| |||  |||| ||  a
         agagu uggcauug gagauuucucuucg gaa  acaa ag a
----cgaaa     u        u              c   --    a  a

References

  • LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis. Lu Z, Xiao Z, Wang Q, Pan C, Xia Y, Wu W, Chen L. Cancer Biomark. 2023;38(3):379-391.

  • Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS. Du Z, Yuan J, Wu Z, Chen Q, Liu X, Jia J. Endocrinology. 2022 Oct 11;163(11):bqac138.

  • Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells. Sun Y, Cao B, Zhou J. BMC Cancer. 2020 May 18;20(1):434.

  • MicroRNA-518-3p suppresses cell proliferation, invasiveness, and migration in colorectal cancer via targeting Yang H, Ren J, Bai Y, Jiang J, Xiao S. Biochem Cell Biol. 2020 Oct;98(5):575-582.

  • Serum miR-518e-5p is a potential biomarker for secondary imatinib-resistant gastrointestinal stromal tumor. Kou Y, Yang R, Wang Q. J Biosci. 2018 Dec;43(5):1015-1023.

  • Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. Feng C, Xian Q, Liu S. Biomed Pharmacother. 2018 Jan;97:1595-1602.

  • MicroRNA Species in Follicular Fluid Associating With Polycystic Ovary Syndrome and Related Intermediary Phenotypes. Sørensen AE, Wissing ML, Englund AL, Dalgaard LT. J Clin Endocrinol Metab. 2016 Apr;101(4):1579-89.

  • Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population. Chen J, Zhao X, Wang H, Chen Y, Wang W, Zhou W, Wang X, Tang J, Zhao Y, Lu X, Chen S, Wang L, Shen C, Yang S. Am J Hypertens. 2014 Oct;27(10):1268-76.

  • Hydroxysteroid (17-β) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia. Ishibashi O, Ohkuchi A, Ali MM, Kurashina R, Luo SS, Ishikawa T, Takizawa T, Hirashima C, Takahashi K, Migita M, Ishikawa G, Yoneyama K, Asakura H, Izumi A, Matsubara S, Takeshita T, Takizawa T. Hypertension. 2012 Feb;59(2):265-73.

  • A mammalian microRNA expression atlas based on small RNA library sequencing. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. Cell. 2007 Jun 29;129(7):1401-14.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.

  • Identification of hundreds of conserved and nonconserved human microRNAs. Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z. Nat Genet. 2005 Jul;37(7):766-70.