Mature miRNA: hsa-miR-4717-5p

Mature miRNA

miRNA Name hsa-miR-4717-5p
miRNA Sequence 5' - uaggccacagccacccaugugu - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0019829

Precursor miRNA

Precursor Name hsa-mir-4717
Genomic Location chr16:2274620-2274691 (+); nearby genomic features
Clustered miRNAs hsa-mir-3677,hsa-mir-940,hsa-mir-4717 (within 10kb in genome)
NCBI GENE ID 100616241
miRBase ID MI0017352
Precursor Sequence 
                                 gg
ggcaguguuuaggccacagccacccauguguag  g
|||||||||||||||||||||||||||||||||  
ccgucacaaauccggugucgguggguacacauc  u
                                 gg

References

  • Fusobacterium nucleatum induces excess methyltransferase-like 3-mediated microRNA-4717-3p maturation to promote colorectal cancer cell proliferation. Xu Q, Lu X, Li J, Feng Y, Tang J, Zhang T, Mao Y, Lan Y, Luo H, Zeng L, Xiang Y, Hu L, Zhang Y, Li Q, Deng L, He X, Tang B, Mao X, Zeng D. Cancer Sci. 2022 Nov;113(11):3787-3800.

  • Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma. Kunou S, Shimada K, Takai M, Sakamoto A, Aoki T, Hikita T, Kagaya Y, Iwamoto E, Sanada M, Shimada S, Hayakawa F, Oneyama C, Kiyoi H. Oncogene. 2021 Jun;40(23):3989-4003.

  • Alteration of microRNA-4474/4717 expression and CREB-binding protein in human colorectal cancer tissues infected with Fusobacterium nucleatum. Feng YY, Zeng DZ, Tong YN, Lu XX, Dun GD, Tang B, Zhang ZJ, Ye XL, Li Q, Xie JP, Mao XH. PLoS One. 2019 Apr 5;14(4):e0215088.

  • MicroRNA expression profiling in Guillain-Barré syndrome. Lv Z, Shi Q, Huang W, Xing C, Hao Y, Feng X, Yang Y, Zhang A, Kong Q, Yuki N, Wang Y. J Neuroimmunol. 2016 Dec 15;301:12-15.

  • microRNA-4717 differentially interacts with its polymorphic target in the PD1 3' untranslated region: A mechanism for regulating PD-1 expression and function in HBV-associated liver diseases. Zhang G, Li N, Li Z, Zhu Q, Li F, Yang C, Han Q, Lv Y, Zhou Z, Liu Z. Oncotarget. 2015 Aug 7;6(22):18933-44.

  • MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits. Hommers L, Raab A, Bohl A, Weber H, Scholz CJ, Erhardt A, Binder E, Arolt V, Gerlach A, Gloster A, Kalisch R, Kircher T, Lonsdorf T, Ströhle A, Zwanzger P, Mattheisen M, Cichon S, Lesch KP, Domschke K, Reif A, Lohse MJ, Deckert J. Am J Med Genet B Neuropsychiatr Genet. 2015 Jun;168B(4):296-306.

  • Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C. Cancer Res. 2011 Jan 1;71(1):78-86.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.