Mature miRNA: hsa-miR-4520-5p

Mature miRNA

miRNA Name hsa-miR-4520-5p
Previous Name hsa-miR-4520a-5p
miRNA Sequence 5' - ccugcguguuuucuguccaa - 3' (length = 20)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0019235

Precursor miRNA

Precursor Name hsa-mir-4520-1
Genomic Location chr17:6655440-6655509 (-); nearby genomic features
Clustered miRNAs hsa-mir-4520-1,hsa-mir-4520-2 (within 10kb in genome)
NCBI GENE ID 100616401
miRBase ID MI0016886
Precursor Sequence 
-gugugcca                       ag
         ccugcguguuuucuguccaaauc  a
         |||||||||||||||||||||||   a
         ggacgcacaaaagacagguuuag  a
aaggaagaa                       ga
Precursor Name hsa-mir-4520-2
Genomic Location chr17:6655449-6655502 (+); nearby genomic features
Clustered miRNAs hsa-mir-4520-1,hsa-mir-4520-2 (within 10kb in genome)
NCBI GENE ID 100616466
miRBase ID MI0017358
Precursor Sequence 
-                       cu
 ccugcguguuuucuguccaaauc  u
 |||||||||||||||||||||||   u
 ggacgcacaaaagacagguuuag  u
u                       uc

References

  • Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF). Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Vlachos GS, Häupl T, Radbruch A, Sidiropoulos P, Doukoumetzidis K, Kardassis D, Niewold TB, Boumpas DT, Goulielmos GN. J Cell Physiol. 2017 Jun;232(6):1326-1336.

  • Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. Joyce CE, Zhou X, Xia J, Ryan C, Thrash B, Menter A, Zhang W, Bowcock AM. Hum Mol Genet. 2011 Oct 15;20(20):4025-40.

  • Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C. Cancer Res. 2011 Jan 1;71(1):78-86.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q, How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE, Chadburn A, Dave SS; Hematologic Malignancies Research Consortium. Blood. 2010 Dec 2;116(23):e118-27.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.