Mature miRNA: hsa-miR-4463

Mature miRNA

miRNA Name hsa-miR-4463
miRNA Sequence 5' - gagacugggguggggcc - 3' (length = 17)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0018987

Precursor miRNA

Precursor Name hsa-mir-4463
Genomic Location chr6:75428407-75428473 (+); nearby genomic features
NCBI GENE ID 100616389
miRBase ID MI0016811
Precursor Sequence 
aa      -auu    a     u        uga
  uagauu    gguc ccacc ccaguuuc   a
  ||||||    |||| ||||| ||||||||    u
  guuuaa    ccgg ggugg ggucagag   u
-c      gagu    -     -        ugu

References

  • miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells. He X, Wu F, Zhou Y, Wu J, Long Y, Zhou X. Front Biosci (Landmark Ed). 2022 Jun 1;27(6):175.

  • MicroRNA-4463 facilitates the development of colon cancer by suppression of the expression of PPP1R12B. Tan J, Lu T, Xu J, Hou Y, Chen Z, Zhou K, Ding Y, Jiang B, Zhu Y. Clin Transl Oncol. 2022 Jun;24(6):1115-1123.

  • Downregulation of MicroRNA-4463 Attenuates High-Glucose- and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS. He X, Du C, Zou Y, Long Y, Huang C, Chen F, He Y, Zhou X. Cell Physiol Biochem. 2018;49(5):2073-2087.

  • MiR-4463 inhibits the migration of human aortic smooth muscle cells by AMOT. Wang X, Du C, He X, Deng X, He Y, Zhou X. Biosci Rep. 2018 Sep 20;38(5):BSR20180150.

  • Roles of miR‑4463 in H2O2‑induced oxidative stress in human umbilical vein endothelial cells. Wang X, He X, Deng X, He Y, Zhou X. Mol Med Rep. 2017 Sep;16(3):3242-3252.

  • Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans. He XM, Zheng YQ, Liu SZ, Liu Y, He YZ, Zhou XY. J Atheroscler Thromb. 2016;23(2):196-206.

  • Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q, How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE, Chadburn A, Dave SS; Hematologic Malignancies Research Consortium. Blood. 2010 Dec 2;116(23):e118-27.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.