Mature miRNA: hsa-miR-4286



Mature miRNA

miRNA Name hsa-miR-4286
miRNA Sequence 5' - accccacuccugguacc - 3' (length = 17)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0016916

Precursor miRNA

Precursor Name hsa-mir-4286
Genomic Location chr8:10666978-10667070 (+); nearby genomic features
NCBI GENE ID 100422982
miRBase ID MI0015894
Precursor Sequence
--uac   u g    c   -----  c      -      ca   -   a
     uua g cacc cac     uc ugguac cauagu  uaa guu g
     ||| | |||| |||     || |||||| ||||||  ||| ||| 
     aau c gugg gug     ag accaug gugucg  auu uag g
guaca   u g    u   aauuc  u      a      ag   g   a

References


  • miR-4286 functions in osteogenesis and angiogenesis via targeting histone deacetylase 3 and alleviates alcohol-induced bone loss in mice. Yu H, Wang K, Liu P, Luo P, Zhu D, Yin J, Yang Q, Huang Y, Gao J, Ai Z, Chen Y, Gao Y. Cell Prolif. 2021 Jun;54(6):e13054.

  • Prospective Study on Plasma MicroRNA-4286 and Incident Acute Coronary Syndrome. Shen M, Xu X, Liu X, Wang Q, Li W, You X, Peng R, Yuan Y, Long P, Niu R, Yang H, Cheng X, Pan A, Tanguay RM, Zhang X, He M, Wang C, Liang L, Wu T. J Am Heart Assoc. 2021 Mar 16;10(6):e018999.

  • NF-κB/miR-18a-3p and miR-4286/BZRAP1 axis may mediate carcinogenesis in Helicobacter pylori-Associated gastric cancer. Tsai CC, Chen TY, Tsai KJ, Lin MW, Hsu CY, Wu DC, Tsai EM, Hsieh TH. Biomed Pharmacother. 2020 Dec;132:110869.

  • miR-4286 is Involved in Connections Between IGF-1 and TGF-β Signaling for the Mesenchymal Transition and Invasion by Glioblastomas. Ho KH, Chen PH, Shih CM, Lee YT, Cheng CH, Liu AJ, Lee CC, Chen KC. Cell Mol Neurobiol. 2022 Apr;42(3):791-806.

  • miR-4286/TGF-β1/Smad3-Negative Feedback Loop Ameliorated Vascular Endothelial Cell Damage by Attenuating Apoptosis and Inflammatory Response. He Z, Xue H, Liu P, Han D, Xu L, Zeng X, Wang J, Yang B, Luo B. J Cardiovasc Pharmacol. 2020 May;75(5):446-454.

  • miR-4286 promotes prostate cancer progression by targeting the expression of SALL1. Li Z, Zhao S, Wang H, Zhang B, Zhang P. J Gene Med. 2023 Jul;25(7):e3127.

  • Overexpression of miR-4286 is an unfavorable prognostic marker in individuals with non-small cell lung cancer. An X, Ge J, Guo H, Mi H, Zhou J, Liu Y, Weiyue, Wu Z. J Cell Biochem. 2019 Oct;120(10):17573-17583.

  • MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer. Ling C, Wang X, Zhu J, Tang H, Du W, Zeng Y, Sun L, Huang JA, Liu Z. Cancer Med. 2019 Jul;8(7):3520-3531.

  • MicroRNA-4286 promotes esophageal carcinoma development by targeting INPP4A to evoke the JAK2/STAT3 pathway activation. Zhang M, Tian H, Li R, Yan W, Xu R. Pharmazie. 2018 Jun 1;73(6):342-348.

  • Antiproliferative and Pro-Apoptotic Effects of MiR-4286 Inhibition in Melanoma Cells. Komina A, Palkina N, Aksenenko M, Tsyrenzhapova S, Ruksha T. PLoS One. 2016 Dec 22;11(12):e0168229.

  • Association of MicroRNAs and YRNAs With Platelet Function. Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Circ Res. 2016 Feb 5;118(3):420-432.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE, Hart RP. PLoS One. 2009 Sep 28;4(9):e7192.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.