Mature miRNA: hsa-miR-4284

Mature miRNA

miRNA Name hsa-miR-4284
miRNA Sequence 5' - gggcucacaucaccccau - 3' (length = 18)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0016915

Precursor miRNA

Precursor Name hsa-mir-4284
Genomic Location chr7:73711317-73711397 (+); nearby genomic features
NCBI GENE ID 100422948
miRBase ID MI0015893
Precursor Sequence 
---g      ga       -ac  c     --a  aaa    g
    uucugu  ggggcuc   au acccc   uc   gugg g
    ||||||  |||||||   || |||||   ||   |||| 
    gagaua  uuucgag   ug ugggg   ag   uacu a
ggcg      -g       gau  a     gag  ggg    c

References

  • MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1. Sun D, Shang D, Miao P, Jiang Z, Chen Y, Gao J. Anticancer Drugs. 2022 Sep 1;33(8):701-709.

  • Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284. Wang H, Wang D, Wei Q, Li C, Li C, Yang J. Bioengineered. 2022 Apr;13(4):9872-9884.

  • MiR-4282 contributes to inhibit pancreatic cancer metastasis by negatively interacting with ABCB5. Li X, Hou YS. Eur Rev Med Pharmacol Sci. 2020 Oct;24(19):9915-9923.

  • Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis. Liu W, Wang P, Xie Z, Wang S, Ma M, Li J, Li M, Cen S, Tang S, Zheng G, Ye G, Wu X, Wu Y, Shen H. Cell Death Dis. 2019 Feb 25;10(3):188.

  • MicroRNA‑4284 promotes gastric cancer tumorigenicity by targeting ten-eleven translocation 1. Li Y, Shen Z, Jiang H, Lai Z, Wang Z, Jiang K, Ye Y, Wang S. Mol Med Rep. 2018 May;17(5):6569-6575.

  • Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans. He XM, Zheng YQ, Liu SZ, Liu Y, He YZ, Zhou XY. J Atheroscler Thromb. 2016;23(2):196-206.

  • A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D. Inflamm Bowel Dis. 2015 May;21(5):996-1005.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE, Hart RP. PLoS One. 2009 Sep 28;4(9):e7192.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.