Mature miRNA: hsa-miR-374c-3p

Mature miRNA

miRNA Name hsa-miR-374c-3p
miRNA Sequence 5' - cacuuagcagguuguauuauau - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0022735

Precursor miRNA

Precursor Name hsa-mir-374c
Genomic Location chrX:74218549-74218618 (+); nearby genomic features
Clustered miRNAs hsa-mir-421,hsa-mir-374b,hsa-mir-374c (within 10kb in genome)
NCBI GENE ID 100500807
miRBase ID MI0016684
Precursor Sequence 
aca    caaug                    cu
   cgga     auaauacaaccugcuaagug  a
   ||||     ||||||||||||||||||||  
   gccu     uauuauguuggacgauucac  g
uga    accua                    ag

References

  • miR‑374c‑5p regulates PTTG1 and inhibits cell growth and metastasis in hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Yang G, Xiog Y, Wang G, Li W, Tang T, Sun J, Li J. Mol Med Rep. 2022 Apr;25(4):148.

  • MicroRNA-374c-5p inhibits the development of breast cancer through TATA-box binding protein associated factor 7-mediated transcriptional regulation of DEP domain containing 1. Hao S, Tian W, Chen Y, Wang L, Jiang Y, Gao B, Luo D. J Cell Biochem. 2019 Sep;120(9):15360-15368.

  • miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, Griffiths-Jones S. Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7.

  • Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. Witten D, Tibshirani R, Gu SG, Fire A, Lui WO. BMC Biol. 2010 May 11;8:58.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.