Mature miRNA: hsa-miR-3646

Mature miRNA

miRNA Name hsa-miR-3646
miRNA Sequence 5' - aaaaugaaaugagcccagccca - 3' (length = 22)
Predicted Targets miRDB
Validated Targets TarBase
miRBase ID MIMAT0018065

Precursor miRNA

Precursor Name hsa-mir-3646
Genomic Location chr20:44408120-44408203 (+); nearby genomic features
NCBI GENE ID 100500813
miRBase ID MI0016046
Precursor Sequence 
u     a                      ug   ---a   u
 ucagu gguuggguucauuucauuuuca  aca    ccc a
 ||||| ||||||||||||||||||||||  |||    |||  u
 aguua ccgacccgaguaaaguaaaagu  ugu    ggg a
a     c                      gu   aaaa   u

References

  • MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model. Liu R, Zhong L, Wang C, Sun Y, Ru W, Dai W, Yang S, Zhong A, Xie X, Chen X, Li S. Clin Exp Hypertens. 2023 Dec 31;45(1):2166948.

  • MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway. Wang C, Cheng B. Bioengineered. 2022 Mar;13(3):4869-4884.

  • microRNA-3646 serves as a diagnostic marker and mediates the inflammatory response induced by acute coronary syndrome. Yu J, Li Y, Leng D, Cao C, Yu Y, Wang Y. Bioengineered. 2021 Dec;12(1):5632-5640.

  • Identification of microRNAs in Nipple Discharge as Potential Diagnostic Biomarkers for Breast Cancer. Zhang K, Zhao S, Wang Q, Yang HS, Zhu J, Ma R. Ann Surg Oncol. 2015 Dec;22 Suppl 3:S536-44.

  • Discovery of microRNAs and other small RNAs in solid tumors. Meiri E, Levy A, Benjamin H, Ben-David M, Cohen L, Dov A, Dromi N, Elyakim E, Yerushalmi N, Zion O, Lithwick-Yanai G, Sitbon E. Nucleic Acids Res. 2010 Oct;38(18):6234-46.

  • miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.